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G-protein coupled opioid receptor that functions to be a receptor for endogenous alpha-neoendorphins and dynorphins, but has minimal affinity for beta-endorphins. Also features like a receptor for many artificial opioids and to the psychoactive diterpene salvinorin A. Ligand binding leads to a conformation change that triggers signaling by using guanine nucleotide-binding proteins (G proteins) and modulates the action of down-stream effectors, such as adenylate cyclase.
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